The EFL Sky Bet League One fixtures have given United a trip to relegated Derby County in the season's opening game.
The U's will visit Pride Park for the first game of the season to take on relegated Derby County, with the game scheduled to take place at 3pm on Saturday 30th July.
This is followed the next weekend by a home game against Cambridge United ahead of the first round of the Carabao Cup, the draw for which will take place at 2.30 this afternoon. United then face a trip to newly promoted Bristol Rovers.
United travel to Ipswich Town on Boxing Day, followed by home games against Charlton Athletic and Exeter City - the first match of 2023. Over Easter, Oxford welcome Sheffield Wednesday on Good Friday and have a trip to Port Vale on Easter Monday.
United's final league game is at home against Accrington Stanley on Saturday 6th May.
The full fixture list is as follows:
| Sat 30 July | Derby County | A |
| Sat 06 Aug | Cambridge United | H |
| Wed 10 Aug | Carabao Cup 1 | |
| Sat 13 Aug | Bristol Rovers | A |
| Tue 16 Aug | Lincoln City | H |
| Sat 20 Aug | Morecambe | H |
| Wed 24 Aug | Carabao Cup 2 | |
| Sat 27 Aug | Cheltenham Town | A |
| Sat 03 Sep | Burton Albion | H |
| Sat 10 Sep | Shrewsbury Town | A |
| Tue 13 Sep | Plymouth Argyle | A |
| Sat 17 Sep | MK Dons | H |
| Sat 24 Sep | Fleetwood Town | H |
| Sat 01 Oct | Charlton Athletic | A |
| Sat 08 Oct | Wycombe Wanderers | H |
| Sat 15 Oct | Exeter City | A |
| Sat 22 Oct | Peterborough United | H |
| Tue 25 Oct | Portsmouth | A |
| Sat 29 Oct | Bolton Wanderers | A |
| Sat 05 Nov | Emirates FA Cup 1 | |
| Sat 12 Nov | Port Vale | H |
| Sat 19 Nov | Forest Green Rovers | H |
| Sat 26 Nov | Emirates FA Cup 2 | |
| Sat 03 Dec | Accrington Stanley | A |
| Sat 10 Dec | Barnsley | H |
| Sat 17 Dec | Sheffield Wednesday | A |
| Mon 26 Dec | Ipswich Town | A |
| Thu 29 Dec | Charlton Athletic | H |
| Sun 01 Jan | Exeter City | H |
| Sat 07 Jan | Wycombe Wanderers | A |
| Sat 14 Jan | Fleetwood Town | A |
| Sat 21 Jan | Ipswich Town | H |
| Sat 28 Jan | Burton Albion | A |
| Sat 04 Feb | Shrewsbury Town | H |
| Sat 11 Feb | MK Dons | A |
| Tue 14 Feb | Plymouth Argyle | H |
| Sat 18 Feb | Cambridge United | A |
| Sat 25 Feb | Bristol Rovers | H |
| Sat 04 Mar | Lincoln City | A |
| Sat 11 Mar | Derby County | H |
| Sat 18 Mar | Morecambe | A |
| Sat 25 Mar | Cheltenham Town | H |
| Sat 01 Apr | Peterborough United | A |
| Fri 07 Apr | Sheffield Wednesday | H |
| Mon 10 Apr | Port Vale | A |
| Sat 15 Apr | Bolton Wanderers | H |
| Tue 18 Apr | Portsmouth | H |
| Sat 22 Apr | Barnsley | A |
| Sat 29 Apr | Forest Green Rovers | A |
| Sat 06 May | Accrington Stanley | H |
All Saturday games plus Boxing Day/New Years Day/Easter fixtures are 3pm kick offs. All Tuesday games plus 29th December are 7.45pm kick offs
All fixtures are subject to change